A widely used peptide-aldehyde proteasome inhibitor for blocking intracellular protein degradation.
Selleck MG132 is a potent proteasome inhibitor that blocks the chymotrypsin-like, trypsin-like and peptidyl-glutamyl activities of the proteasome. It is frequently used to inhibit 26S proteasome-mediated protein degradation and study ubiquitination, NF-κB signaling, apoptosis and cellular stress.
Brand: Selleck Chemicals
Catalog number: S2619
Primary target: 26S proteasome
Additional target: Calpain
Synonym: Z-Leu-D-Leu-Leu-al
CAS number: 1211877-36-9
Molecular weight: 475.62
Official product link: MG132 – S2619 Selleck Chemicals
