A selective ALK4, ALK5 and ALK7 inhibitor for blocking TGF-β signaling.
SB 431542 is an ATP-competitive inhibitor of activin receptor-like kinases ALK4, ALK5 and ALK7. It blocks TGF-β-mediated Smad2 phosphorylation and is frequently used in studies involving TGF-β signaling, cell differentiation, fibrosis, organoid culture and stem-cell maintenance.
Manufacturer: APExBIO
Catalog number: A8249
CAS number: 301836-41-9
Targets: ALK4, ALK5 and ALK7
Reported activity: ALK5 IC50 approximately 94 nM
Available sizes: Evaluation sample, 10 mM in 1 mL DMSO, 10 mg and 50 mg
Storage: Store at −20°C
Applications: TGF-β signaling, fibrosis, stem cells, organoids and differentiation research
Research use only: Not for diagnostic or therapeutic use
Original product link: https://www.apexbt.com/sb-431542.html
Contact Biolterna for current availability, bulk quantities or alternative TGF-β receptor inhibitors.
