A potent GPX4 inhibitor commonly used to induce ferroptosis in cultured cells.
RSL3 is a small-molecule inhibitor of glutathione peroxidase 4, an antioxidant enzyme that protects cellular membranes against lipid peroxidation. Inhibition of GPX4 promotes the accumulation of lipid reactive oxygen species and induces ferroptotic cell death.
Manufacturer: APExBIO
Catalog number: B6095
CAS number: 1219810-16-8
Target: GPX4
Reported activity: IC50 approximately 100 nM
Available sizes: 2 mg, 5 mg, 10 mg, 25 mg, 50 mg and 100 mg
Storage: Store at −20°C
Applications: Ferroptosis, GPX4 signaling and oxidative cell-death research
Research use only: Not for diagnostic or therapeutic use
Original product link: https://www.apexbt.com/rsl3.html
Contact Biolterna for current availability, larger quantities or other GPX4-targeting compounds.
