A potent proteasome and calpain inhibitor used to study protein degradation, autophagy and apoptosis.
MCE MG-132 is a peptide-aldehyde inhibitor of the proteasome and calpain. It inhibits the proteolytic activity of the 26S proteasome complex and is widely used to prevent ubiquitin-dependent protein degradation.
MG-132 is commonly used to investigate proteostasis, ubiquitination, transcription-factor regulation, autophagy and apoptosis. MCE reports IC₅₀ values of approximately 100 nM for proteasome inhibition and 1.2 μM for calpain inhibition.
Manufacturer: MedChemExpress
Catalog number: HY-13259
Product name: MG-132
Synonym: Z-Leu-Leu-Leu-al
CAS number: 133407-82-6
Molecular formula: C₂₆H₄₁N₃O₅
Molecular weight: 475.62 g/mol
Targets: Proteasome and calpain
Form: Solid
Purity: Refer to the current lot-specific COA
Available sizes: Multiple pack sizes available
Applications: Protein degradation, ubiquitination, proteasome studies, autophagy and apoptosis research
Research use only: Not for human or veterinary use
Original product link: MCE MG-132 product page
Contact Biolterna for current sizes, batch-specific purity, COA, solubility information or bulk supply.
The official MCE product information identifies HY-13259 as MG-132 and reports its proteasome and calpain inhibitory activity.
