A potent GSK-3α/β inhibitor widely used in stem-cell culture, differentiation and Wnt signaling research.
Selleck Laduviglusib, commonly known as CHIR-99021 hydrochloride, is a selective GSK-3α/β inhibitor with reported IC50 values of 10 and 6.7 nM. By inhibiting GSK-3, it activates Wnt/β-catenin signaling and is widely used in stem-cell maintenance, cellular reprogramming and differentiation protocols.
Brand: Selleck Chemicals
Catalog number: S2924
Primary targets: GSK-3α and GSK-3β
Reported activity: IC50 10 nM and 6.7 nM
Synonyms: CHIR-99021 HCl, CT99021 HCl
CAS number: 1797989-42-4
Molecular weight: 501.8
Official product link: CHIR-99021 Hydrochloride – S2924
