A ferroptosis inducer that inhibits cystine uptake and promotes iron-dependent oxidative cell death.
MCE Erastin is a widely used ferroptosis inducer. It blocks cystine uptake mediated by system Xc⁻ and SLC7A11, reducing intracellular glutathione availability and increasing susceptibility to lipid peroxidation.
Erastin has also been associated with voltage-dependent anion channel signaling and accumulation of reactive oxygen species. It is commonly used with ferroptosis inhibitors such as Ferrostatin-1 as an experimental control.
Manufacturer: MedChemExpress
Catalog number: HY-15763
Product name: Erastin
CAS number: 571203-78-6
Molecular formula: C₃₀H₃₁ClN₄O₄
Molecular weight: 547.04 g/mol
Targets: SLC7A11, system Xc⁻ and VDAC-associated pathways
Biological effect: Ferroptosis induction
Form: Solid
Purity: Refer to the current lot-specific COA
Available sizes: Multiple pack sizes available
Applications: Ferroptosis, oxidative stress, cystine metabolism and cancer research
Research use only: Not for human or veterinary use
Original product link: MCE Erastin product page
Contact Biolterna for current sizes, availability, batch-specific COA and solubility information.
The official MCE information confirms catalog HY-15763, CAS 571203-78-6 and its activity as a ferroptosis inducer associated with SLC7A11 and VDAC signaling.
