A highly potent mTORC1 inhibitor and autophagy activator widely used in cell-signaling and aging research.
Selleck Rapamycin (Sirolimus) is a specific mTOR inhibitor with an IC50 of approximately 0.1 nM in HEK293 cells. It binds FKBP12 and acts as an allosteric inhibitor of mTORC1. Rapamycin is widely used to investigate autophagy, cell growth, metabolism, immune regulation and aging-related pathways.
Brand: Selleck Chemicals
Catalog number: S1039
Primary target: mTORC1
Reported activity: IC50 approximately 0.1 nM in HEK293 cells
Alternative name: Sirolimus
CAS number: 53123-88-9
Molecular weight: 914.18
Form: Powder
Research use only: Not for diagnostic or therapeutic use
Official product link: Rapamycin (Sirolimus) – S1039
