A V-ATPase inhibitor commonly used to block lysosomal acidification and late-stage autophagy.
MCE Bafilomycin A1 is a selective and reversible inhibitor of vacuolar-type H⁺-ATPase. It prevents normal acidification of lysosomes and other intracellular acidic compartments.
Bafilomycin A1 is frequently used as a late-stage autophagy inhibitor because it interferes with lysosomal function, protein degradation and autophagic flux. It is also used in studies of apoptosis, infection and intracellular trafficking.
Manufacturer: MedChemExpress
Catalog number: HY-100558
Product name: Bafilomycin A1
Synonym: BafA1
CAS number: 88899-55-2
Molecular formula: C₃₅H₅₈O₉
Molecular weight: 622.83 g/mol
Targets: V-ATPase and proton pump
Biological effect: Inhibition of lysosomal acidification and autophagic flux
Form: Solid
Purity: Refer to the current lot-specific COA
Available sizes: Multiple pack sizes available
Applications: Autophagy, lysosomal biology, intracellular trafficking, apoptosis and infection research
Research use only: Not for human or veterinary use
Original product link: MCE Bafilomycin A1 product page
Contact Biolterna for current sizes, availability, batch-specific COA and handling information.
MCE identifies HY-100558 as Bafilomycin A1 and describes it as a reversible V-ATPase inhibitor used to block autophagic flux.
