A potent ferroptosis inhibitor that protects membrane lipids from oxidative damage.
MCE Ferrostatin-1, also known as Fer-1, is a potent and selective inhibitor of ferroptosis. It acts as a synthetic antioxidant that suppresses lipid peroxidation and protects cell membranes from oxidative damage.
Ferrostatin-1 is widely used as a rescue compound in experiments involving ferroptosis induced by Erastin, RSL3, glutamate or other oxidative stressors. MCE reports an EC₅₀ value of approximately 60 nM against Erastin-induced ferroptosis in HT-1080 cells.
Manufacturer: MedChemExpress
Catalog number: HY-100579
Product name: Ferrostatin-1
Synonym: Fer-1
CAS number: 347174-05-4
Molecular formula: C₁₅H₂₂N₂O₂
Molecular weight: 262.35 g/mol
Target: Ferroptosis
Biological effect: Inhibition of lipid peroxidation and ferroptotic cell death
Form: Solid
Purity: Refer to the current lot-specific COA
Available sizes: Multiple pack sizes available
Applications: Ferroptosis, oxidative stress, lipid peroxidation, neuroscience and cancer research
Research use only: Not for human or veterinary use
Original product link: MCE Ferrostatin-1 product page
Contact Biolterna for current sizes, availability, batch-specific COA and storage information.
MCE identifies HY-100579 as Ferrostatin-1 and reports inhibition of Erastin-induced ferroptosis in HT-1080 cells.
