A selective PARP1/2 inhibitor widely used in DNA-damage repair and synthetic-lethality research.
Selleck Olaparib is a selective PARP1 and PARP2 inhibitor with reported IC50 values of 5 and 1 nM. It is widely used to investigate DNA single-strand-break repair, BRCA-associated synthetic lethality, replication stress and cancer-cell responses.
Brand: Selleck Chemicals
Catalog number: S1060
Primary targets: PARP1 and PARP2
Reported activity: IC50 5 nM and 1 nM
Synonyms: AZD2281, KU0059436
CAS number: 763113-22-0
Molecular weight: 434.46
Official product link: AZD2281 (Olaparib) – S1060 Selleck Chemicals
