Santa Cruz Biotechnology is best known for its extensive catalog of research antibodies. Many laboratories recognize the brand through its distinctive catalog numbers beginning with “sc-”, which appear frequently in published Western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation protocols.
Antibodies remain the core of the portfolio, but Santa Cruz Biotechnology is no longer limited to antibody products. Its current catalog also includes gene-editing reagents, siRNA and shRNA products, research chemicals, purified proteins, detection reagents, membranes, molecular weight markers, and general laboratory supplies.
Santa Cruz Biotechnology offers monoclonal, recombinant monoclonal, and polyclonal primary antibodies. The catalog covers established research targets as well as proteins that may be difficult to source from larger general laboratory suppliers.
The antibodies are used in:
Major target areas include tumor suppressors, apoptosis proteins, transcription factors, kinases, phosphatases, membrane receptors, structural proteins, transport proteins, and neuronal markers.
Popular Santa Cruz antibodies include products for p53, c-Myc, NF-κB, beta-actin, GAPDH, tubulin, cyclins, CDKs, BCL-2 family proteins, caspases, and steroid hormone receptors.
Searching only by protein name is not enough when selecting a Santa Cruz antibody. A single target may have several clones with different host species, immunogens, recommended applications, and species reactivity.
The most useful information to confirm before ordering includes:
This is especially important for older “sc-” catalog numbers. Some widely cited products have been discontinued or replaced, while other targets now have recombinant monoclonal alternatives.
For published experiments, matching the exact catalog number and clone is usually safer than choosing another antibody against the same target.
Santa Cruz antibodies cover many of the proteins that researchers use to study cancer development, cell proliferation, DNA damage, and programmed cell death.
Relevant pathways and targets include:
The catalog is useful for both exploratory research and routine detection of established cellular markers.
Neurobiology has long been a visible part of the Santa Cruz Biotechnology antibody range. Researchers can find products targeting receptors, ion channels, neurotransmitter systems, synaptic proteins, glial markers, and proteins associated with neurodegenerative disease.
Common research areas include:
Because brain tissue and neuronal samples often contain closely related protein isoforms, researchers should review the immunogen region and known cross-reactivity before selecting an antibody.
Santa Cruz Biotechnology supplies secondary antibodies against commonly used host species. Available conjugates support colorimetric, chemiluminescent, fluorescent, and flow cytometry workflows.
Formats include:
Researchers should match the secondary antibody to the host species and immunoglobulin class of the primary antibody. Highly cross-adsorbed products may be preferable for multiplex staining or samples containing immunoglobulins from several species.
The brand offers supporting reagents for protein extraction, electrophoresis, transfer, blocking, and signal detection. This allows customers to purchase both primary antibodies and the accompanying Western blot reagents from the same source.
Relevant products include:
Control lysates can be particularly helpful when validating a new antibody or troubleshooting a weak signal.
Santa Cruz Biotechnology supplies siRNA, shRNA, and CRISPR products for loss-of-function and gene-regulation studies.
The gene-editing range includes:
These products allow researchers to connect protein detection with functional validation. An antibody can measure the target protein, while siRNA, shRNA, or CRISPR reagents help determine how reducing or activating that target affects the cell.
The Santa Cruz catalog includes inhibitors, activators, substrates, antibiotics, peptides, amino acids, lipids, dyes, probes, solvents, and general biochemical reagents.
Researchers can source compounds for:
When ordering a biochemical, the chemical name alone may not identify the correct product. The catalog number, purity, molecular form, package size, and storage conditions should also be checked.
Santa Cruz Biotechnology offers biologically active proteins, purified antigens, peptides, and related assay products. These reagents can support antibody blocking experiments, immunization studies, enzyme assays, and protein interaction research.
The catalog also includes cell lysates and transfected lysates that express specific target proteins. These materials provide practical positive controls when suitable biological samples are difficult to obtain.
In addition to research reagents, Santa Cruz Biotechnology sells commonly used laboratory products such as pipettes, pipette tips, centrifuge tubes, multiwell plates, membranes, culture dishes, cryogenic supplies, and PCR consumables.
These products broaden the catalog, but the strongest reason to create a dedicated Santa Cruz Biotechnology brand page remains its antibodies, gene-silencing reagents, and frequently cited “sc-” catalog numbers.
Santa Cruz Biotechnology products are commonly used in:
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