Promega is a global life science company that develops reagents, assay systems, instruments, and integrated workflow solutions for biological research. Its portfolio includes more than 4,000 products for cell biology, nucleic acid analysis, protein research, drug discovery, human identification, and molecular diagnostics.
Promega products support both routine laboratory procedures and advanced research applications. Researchers use them in academic laboratories, pharmaceutical companies, biotechnology businesses, forensic laboratories, and clinical research facilities.
Promega supplies a broad range of molecular biology reagents for DNA and RNA research. Key products include GoTaq® DNA polymerases, PCR master mixes, qPCR reagents, reverse transcription systems, restriction enzymes, DNA ligases, cloning reagents, competent cells, and nucleic acid markers.
The GoTaq product family is widely used for endpoint PCR, hot-start PCR, and quantitative PCR. Ready-to-use master mixes reduce pipetting steps and help improve consistency across routine amplification experiments.
These products support gene expression analysis, genotyping, molecular cloning, sequencing preparation, pathogen research, and other genomics workflows.
Promega offers manual and automated solutions for extracting DNA and RNA from cells, tissues, blood, plasma, formalin-fixed samples, and other biological materials.
The Maxwell® automated purification platform combines prefilled reagent cartridges with magnetic-particle technology. It helps laboratories process samples with less manual handling. Promega also provides Wizard® purification kits, ReliaPrep™ systems, and magnetic-bead reagents for genomic DNA, plasmid DNA, total RNA, viral nucleic acids, and PCR cleanup.
These purification products are suitable for PCR, qPCR, sequencing, cloning, gene expression analysis, and molecular diagnostic research.
Bioluminescent assay technology is one of Promega’s strongest product areas. The portfolio includes NanoLuc®, Nano-Glo®, Dual-Luciferase®, ONE-Glo™, Bright-Glo™, and Steady-Glo® reporter assay systems.
NanoLuc luciferase produces a bright and sensitive luminescent signal. It supports reporter gene analysis, live-cell assays, protein interaction studies, protein trafficking research, and target engagement measurement.
NanoBiT® and NanoBRET® technologies allow researchers to investigate protein-protein interactions, receptor signaling, protein degradation, and compound binding in living cells. These platforms are especially valuable in drug discovery and functional cell biology.
Promega develops cell-based assays for measuring viability, proliferation, cytotoxicity, apoptosis, metabolism, and oxidative stress.
CellTiter-Glo® assays measure cellular ATP as an indicator of viable cells. They are widely used in compound screening, cancer research, and drug-response studies. The RealTime-Glo™ platform enables continuous monitoring of cell viability without destroying the sample.
The CytoTox-Glo™, Caspase-Glo®, and ROS-Glo™ product families support cytotoxicity, caspase activity, apoptosis, and oxidative stress studies. Many of these assays use simple add-mix-measure protocols that work well in multiwell plates and automated screening workflows.
Promega provides assay technologies for small-molecule screening, biologics development, target validation, and mechanism-of-action research.
NanoBRET target engagement assays measure compound binding to selected proteins inside living cells. Promega also offers kinase assays, GPCR assays, pathway reporter systems, immune checkpoint bioassays, antibody-dependent cellular cytotoxicity assays, and cytokine-response assays.
These products help researchers evaluate compound potency, selectivity, cellular activity, receptor signaling, and therapeutic antibody function. Luminescence-based detection also supports miniaturized and high-throughput screening formats.
Promega protein research products cover cell-free expression, protein purification, interaction analysis, mass spectrometry, and protein quantification.
The TNT® coupled transcription and translation systems support rapid cell-free protein expression from DNA or RNA templates. HaloTag®, HiBiT®, and NanoLuc-based technologies help researchers label, detect, purify, and monitor proteins in cells.
Promega also supplies proteases for mass spectrometry sample preparation, including sequencing-grade trypsin. Additional products support protein purification, western blotting, kinase analysis, and protein interaction studies.
Promega offers tools for CRISPR genome editing research, including assays for measuring editing efficiency and studying intracellular target engagement. Reporter systems can help researchers evaluate gene regulation, protein expression, and pathway activity after genome modification.
The GenePrint® cell line authentication system supports short tandem repeat profiling. It helps laboratories confirm the identity of human cell lines and detect sample misidentification or cross-contamination.
Promega is also recognized for PowerPlex® STR amplification systems used in human identification and forensic DNA analysis. Its solutions cover DNA extraction, amplification, capillary electrophoresis, and data interpretation workflows.
These products support forensic casework, database sample processing, relationship testing, and research involving degraded or challenging DNA samples.
Promega instruments are designed to work with its purification and assay technologies. Major platforms include Maxwell automated nucleic acid purification instruments, GloMax® multimode detection systems, and Spectrum Compact CE systems.
GloMax instruments measure luminescence, fluorescence, and absorbance for reporter assays and cell-based experiments. These integrated reagent and instrument workflows help laboratories improve consistency, reduce manual processing, and simplify data collection.
Promega products are used across cancer research, genomics, proteomics, immunology, infectious disease research, neuroscience, metabolic research, cell and gene therapy, translational research, and drug discovery.
The company is particularly strong in bioluminescent assays, cell health analysis, intracellular target engagement, DNA and RNA purification, PCR, protein interaction research, and forensic DNA testing. This broad portfolio allows researchers to connect sample preparation, molecular analysis, functional cell assays, and instrument-based detection within one workflow.
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