New England Biolabs, commonly known as NEB, is a life science reagent manufacturer specializing in enzymes and technologies for molecular biology and genomic research. The company develops products for DNA manipulation, amplification, cloning, sequencing, RNA research, genome editing and protein analysis.

Restriction endonucleases are one of NEB’s best-known product areas. Its portfolio covers a broad selection of restriction enzymes for routine DNA digestion, molecular cloning, mapping and other nucleic acid workflows. NEB also offers High-Fidelity restriction enzymes designed to reduce unwanted star activity, together with compatible buffers, reaction recommendations and online tools for enzyme selection and experimental planning.

For PCR and nucleic acid amplification, NEB supplies DNA polymerases, high-fidelity PCR enzymes, hot-start products, master mixes, reverse transcriptases and reagents for PCR, qPCR and isothermal amplification. Popular product families such as Q5 and OneTaq support applications ranging from routine amplification and colony PCR to cloning, sequencing and amplification of difficult DNA templates.

NEB’s cloning portfolio includes DNA ligases, DNA-modifying enzymes, competent cells and kits for traditional cloning, PCR cloning, site-directed mutagenesis and multi-fragment DNA assembly. NEBuilder HiFi DNA Assembly and Golden Gate Assembly products are widely used in synthetic biology, plasmid construction and the assembly of complex DNA constructs. Researchers can combine these systems with NEB restriction enzymes, polymerases and competent cells to build an integrated cloning workflow.

The company also provides Monarch nucleic acid purification kits for extracting and purifying plasmid DNA, genomic DNA, total RNA and DNA fragments from PCR reactions or agarose gels. Its DNA, RNA and protein markers and ladders support electrophoresis, fragment-size estimation and routine quality control.

For next-generation sequencing, NEB offers library preparation kits, adapters, indexing reagents and enzymatic products for DNA- and RNA-based sequencing workflows. These products support applications such as whole-genome sequencing, targeted sequencing, transcriptome analysis, small RNA sequencing and low-input library preparation.

RNA synthesis and modification represent another important part of the NEB portfolio. Available products include RNA polymerases, capping enzymes, poly(A) polymerase, RNA ligases, ribonucleases, reverse transcriptases and kits for RNA synthesis, processing and analysis. These tools are relevant to RNA biology, mRNA research, transcriptomics and the development of RNA-based technologies.

NEB also supplies CRISPR-associated nucleases and supporting reagents for genome editing, along with products for epigenetics, protein expression, protein purification, glycobiology and cellular analysis. Its protein-related portfolio includes expression systems, affinity purification resins, magnetic beads, protein standards and enzymes for protein modification and analysis.

NEB products are used across molecular biology, genomics, synthetic biology, epigenetics, microbiology, infectious disease research, cancer genetics, gene expression, genome editing and drug discovery. They support workflows ranging from routine DNA digestion and PCR to complex DNA assembly, sequencing library preparation, RNA engineering and recombinant protein production.

Biolterna helps international laboratories and distributors source NEB products according to the required catalog number, enzyme concentration, reaction size, package specification and storage conditions. Customers can send us an individual NEB catalog number or a complete product list to check pricing, availability, lead time and international shipping options. If a requested product is unavailable or exceeds the project budget, we can also help identify compatible alternatives based on enzyme activity, recognition sequence, fidelity, reaction conditions and intended application.

Products are intended for research use only unless otherwise specified by the original manufacturer.